Tottenham manager Thomas Frank has selected four central midfielders as they welcome Chelsea to North London.
It may suggest that someone like Joao Palhinha may drop into the back line, with returning defenders Cristian Romero and Destiny Ugodie only fit enough for the bench.
Chelsea have made 10 changes from the Carabao Cup win at Wolves, playing Malo Gusto in central midfield.
Tottenham XI: Tottenham: Vicario, Danso, Palhinha, Van de Ven, Porro, Bergvall, Sarr, Bentancur, Kudus, Kolo Muani.
Subs: Kinsky, Romero, Udogie, Simons, Odobert, Johnson, Tel, Scarlett, Richarlison
Chelsea XI: Sanchez, James, Fofana, Chalobah, Cucurella, Gusto, Caicedo, Neto, Fernandez, Garnacho, Joao Pedro.
Subs: Jorgensen, Acheampong, Tosin, Hato, Lavia, Andrey Santos, Estevao, Gittens, Guiu